Progesterone Gel is a progesterone-containing vaginal medicine used primarily in specialist reproductive and fertility care. One of the key prescription progesterone gel products in the UK is Crinone 8% Progesterone Vaginal Gel, which contains progesterone at 8% w/w and delivers 90mg progesterone per 1.125g dose.
Progesterone is a naturally occurring steroid hormone that plays an important role in the menstrual cycle, endometrial development, implantation and maintenance of the hormonal environment required during early pregnancy.
The term Progesterone Gel can refer to different formulations in different countries, so the exact concentration, route, manufacturer and approved indication should always be checked against the specific product.
Progesterone Gel may be used when additional progesterone support is required in reproductive medicine.
The major clinical uses associated with prescription vaginal progesterone gel include:
Luteal-phase support:
Progesterone can be used to support the endometrium after ovulation when progesterone supplementation is clinically indicated.
Fertility treatment:
Vaginal progesterone is commonly used in assisted reproductive treatment to provide hormonal support during the luteal phase.
IVF treatment:
Crinone 8% is specifically associated with progesterone support in selected IVF treatment protocols.
Infertility associated with inadequate luteal phase:
Prescription vaginal progesterone may be used where inadequate endogenous progesterone support contributes to infertility.
The exact indication depends on the particular formulation and local product authorization.
Progesterone binds to progesterone receptors in reproductive tissues.
In the endometrium, progesterone promotes transformation of the uterine lining into a secretory state suitable for implantation. It also supports the hormonal environment associated with early pregnancy and contributes to normal regulation of the menstrual cycle.
Vaginal delivery provides a route for progesterone administration directly to the reproductive tract.
Crinone uses a specialized delivery system designed to adhere to vaginal mucosa and provide prolonged progesterone release.
Progesterone Gel is strongly associated with in-vitro fertilisation (IVF) and assisted reproductive treatment.
During IVF, progesterone may be used as luteal-phase support following reproductive procedures. The purpose is to provide progesterone during a period when adequate hormonal support of the endometrium is required.
Search demand around this product is therefore concentrated around terms such as:
Progesterone plays an important role in maintaining an endometrial environment suitable for implantation and early pregnancy.
Vaginal progesterone gel may form part of a fertility clinic’s treatment protocol following embryo transfer. The exact protocol varies according to the treatment cycle, fertility clinic and individual patient circumstances.
Progesterone gel should therefore be used only according to the treatment plan provided by the prescribing fertility specialist.
Crinone 8% is a branded vaginal progesterone gel.
The product contains:
Crinone is a specific branded medicine and should not automatically be treated as interchangeable with every progesterone gel or progesterone cream.
Progesterone gel and progesterone cream are not necessarily the same pharmaceutical product.
A prescription vaginal progesterone gel is specifically formulated for vaginal administration and may have defined fertility-related indications.
A topical progesterone cream may be intended for a completely different route, concentration or purpose.
For this reason, “progesterone gel” and “progesterone cream” should be treated as separate product entities unless the specific manufacturer confirms otherwise.
Progesterone Gel and progesterone capsules contain the same type of active hormone in some products, but they are different dosage forms and routes of administration.
Progesterone capsules may be formulated for oral or vaginal use, depending on the product.
A progesterone gel intended for vaginal use should not automatically be substituted for a capsule because the formulation, absorption and intended clinical application can differ.
Searches for progesterone gel HRT and progesterone gel menopause are common, but these search terms need to be distinguished from fertility-focused vaginal progesterone gel.
Crinone 8% is primarily associated with reproductive and fertility treatment rather than being a general-purpose menopause progesterone product.
For hormone replacement therapy, progesterone may instead be provided through other licensed dosage forms and formulations.
Progesterone has an essential physiological role in pregnancy and some progesterone medicines are used during pregnancy in specific clinical circumstances.
However, not every progesterone gel is authorized for every pregnancy-related indication.
The actual manufacturer’s product information should therefore be checked before making claims about pregnancy use.
A progesterone gel may vary considerably depending on the manufacturer.
Important formulation differences can include:
For Crinone 8%, each applicator delivers 1.125g of gel containing 90mg progesterone.
Progesterone Gel may cause adverse effects that vary according to the formulation and route.
Potential effects include:
Patients should seek medical assessment for severe or unexpected symptoms.
Depending on the exact progesterone gel product, contraindications may include:
The current product-specific prescribing information should always be followed.
The interaction profile depends on the formulation and the medicines being taken at the same time.
A healthcare professional should review the patient’s medication history, particularly when progesterone gel is used alongside:
Do not combine or substitute progesterone products without appropriate medical guidance.
Progesterone gel is one of several progesterone dosage forms used in fertility medicine.
Depending on the treatment protocol, progesterone may be supplied as:
These forms should not automatically be considered therapeutically interchangeable.
Storage conditions depend on the exact product.
For Crinone 8%, the product information specifies storage below 25°C.
The actual manufacturer’s packaging should always be followed because storage requirements can differ between progesterone gel products.
Commercial searches for this product include Progesterone Gel, Progesterone Vaginal Gel, Progesterone Gel 8%, Progesterone 8% Gel, Crinone Progesterone Gel, Crinone 8% Gel, Progesterone Gel IVF, Progesterone Gel Fertility, Progesterone Gel After Embryo Transfer and Progesterone Gel Price.
Availability depends on the exact formulation, manufacturer, country and prescription requirements.
For the UK market, Crinone 8% is the key prescription vaginal progesterone gel product associated with these searches.
The UK product market distinguishes prescription progesterone vaginal gel from progesterone creams and capsules.
Crinone 8% Progesterone Vaginal Gel is the principal UK product entity for searches around progesterone gel and is classified as a prescription-only medicine.
A separate progesterone gel should not automatically be described as generic Crinone unless the specific product has the appropriate regulatory and equivalence basis.
Crinone 8% progesterone vaginal gel is an established Australian product entity and is associated with IVF and assisted reproductive treatment.
Australian searches also show strong demand around:
Search demand in Thailand includes both Crinone 8% progesterone gel and other progesterone gel formulations.
This distinction is important because different progesterone gels can have different concentrations, routes and indications.
Russian-language demand includes searches around progesterone gel, Crinone 8%, vaginal progesterone gel, price and fertility treatment.
Country-specific registration and availability should be checked against the particular product.
Commercial searches in the UAE include Progesterone Gel UAE, Progesterone Gel Dubai, Crinone 8% UAE and Crinone 8% Vaginal Gel Dubai.
Availability and dispensing requirements depend on the product’s local registration and pharmacy requirements.
South Korean search demand includes English and Korean-language progesterone gel terms, including Crinone 8%, progesterone vaginal gel and fertility-related progesterone searches.
The local product name, registration status and formulation should be confirmed for the specific medicine being supplied.
The U.S. market has historically included Crinone progesterone vaginal gel, but current U.S. availability should be verified before making a current retail-supply claim.
U.S. searches remain commercially relevant for terms such as Progesterone Gel USA, Crinone 8% Gel USA, Progesterone Vaginal Gel USA and Progesterone Gel IVF USA.
What is Progesterone Gel?
Progesterone Gel is a pharmaceutical formulation containing progesterone. Vaginal progesterone gel is primarily associated with fertility and reproductive treatment.
What is Crinone 8%?
Crinone 8% is a prescription progesterone vaginal gel containing 8% progesterone and delivering 90mg progesterone per 1.125g dose.
What is Progesterone Gel used for?
Prescription vaginal progesterone gel is used in reproductive medicine, including luteal-phase support and selected IVF and infertility treatment.
Is Progesterone Gel used for IVF?
Yes. Vaginal progesterone gel is used in selected IVF treatment protocols for luteal-phase support.
Is Progesterone Gel used after embryo transfer?
Progesterone supplementation may be part of fertility-treatment protocols following embryo transfer. The exact protocol depends on the fertility specialist and product.
Is Progesterone Gel the same as Crinone?
No. Crinone is a specific branded progesterone vaginal gel. A different progesterone gel may have a different formulation, strength, manufacturer or approved indication.
Is Crinone 8% natural progesterone?
Crinone contains progesterone, the same hormone naturally produced by the human body.
Is Progesterone Gel the same as progesterone cream?
No. Progesterone gels and creams can differ in route, concentration, absorption characteristics and approved uses.
Is Progesterone Gel the same as progesterone tablets?
No. Gel and tablet formulations can differ in route, pharmacokinetics and intended clinical use.
Can Progesterone Gel be used during pregnancy?
Certain progesterone products are used in pregnancy-related care, but the exact indication depends on the product and country.
Is Progesterone Gel prescription-only?
Prescription status depends on the product and country. Crinone 8% is a prescription-only medicine in the UK.
What are common Progesterone Gel side effects?
Possible effects include breast tenderness, headache, dizziness, drowsiness, vaginal irritation, vaginal discharge or residue, spotting and abdominal discomfort.
Does Progesterone Gel help fertility?
Progesterone gel can be used as part of fertility treatment and luteal-phase support where clinically indicated.
Is Progesterone Gel available in the UK?
Yes. Crinone 8% Progesterone Vaginal Gel is a UK prescription medicine. Availability of other progesterone gels depends on their individual product authorization.
Is Progesterone Gel available in Australia?
Yes. Crinone 8% progesterone vaginal gel is an established Australian product.
Is Progesterone Gel available internationally?
Progesterone vaginal gel products are available in multiple countries, but product names, concentrations, registration status and indications vary.
Last Updated: September 19, 2026 | Medically Reviewed By: Licensed Pharmacist
Medical Disclaimer: This information is provided for educational purposes only and is not a substitute for professional medical advice, diagnosis or treatment. Progesterone products vary by formulation, concentration, route and indication. Always verify the specific product information and consult a qualified healthcare professional before starting or changing progesterone treatment.
Orders ship from our India Head Office within 1–2 business days of confirmation. We include full customs documentation — HS codes, certificates of origin, and pharmaceutical export permits.
Estimated delivery: 3–7 business days to UK. 7–10 business days to UAE, Saudi Arabia and Gulf countries. 10–15 days for USA and Asian countries.
All packages arrive in plain, unmarked brown boxes. No pharmacy name or medication details on the outside.
Only logged in customers who have purchased this product may leave a review.
Reviews
There are no reviews yet.