Progesterone 100mg Injection is a prescription progesterone hormone medicine used in specialist reproductive and fertility treatment. Injectable progesterone products containing 100mg progesterone are available in different formulations and concentrations, including 100mg/1mL and 100mg/2mL presentations. Product indications, route, concentration, manufacturer and regulatory status vary by market.
Current market examples include Prontogest 100mg/mL intramuscular injection and Gestone 100mg/2mL injection. Ferring India currently lists progesterone solution for injection at 100mg/2mL, while UK fertility guidance identifies Prontogest 100mg/mL for assisted reproductive treatment.
Prontogest is described by UK fertility services as a 100mg/mL intramuscular progesterone injection, while Ferring India lists progesterone 100mg/2mL solution for injection.
Progesterone is an essential reproductive hormone involved in regulation of the menstrual cycle, development of the endometrium and support of early pregnancy.
Injectable progesterone may be used in specialist reproductive medicine for indications including:
Assisted reproductive technology (ART):
Progesterone supplementation can form part of fertility-treatment protocols to provide luteal-phase support and maintain an appropriate endometrial environment. UK fertility guidance specifically lists Prontogest 100mg/mL injection for ART treatment.
Luteal-phase support:
Progesterone is used to support the luteal phase following fertility treatment where additional progesterone is clinically indicated.
Progesterone replacement:
Certain injectable products are used when progesterone supplementation is required under specialist medical care.
Pregnancy support:
Some progesterone products are used during early pregnancy in specific clinical situations. The precise indication depends on the product, country and treatment protocol.
Progesterone binds to progesterone receptors in reproductive tissues.
It promotes development of the secretory endometrium, helping create the uterine environment associated with implantation and early pregnancy. Progesterone also contributes to regulation of the menstrual cycle and reproductive hormone signalling.
In fertility treatment, progesterone supplementation is used when endogenous progesterone production is insufficient for the treatment protocol or when additional luteal support is clinically indicated.
Progesterone injections are used in some assisted-reproduction protocols as luteal-phase support.
Care Fertility in the UK currently describes Prontogest 100mg/mL as an intramuscular progesterone injection used to support the womb lining and early pregnancy and notes that it is not licensed in the UK.
This makes “progesterone 100mg injection” a useful commercial and informational search entity, but the product page should clearly distinguish the specific injectable product from licensed oral or vaginal progesterone medicines.
Progesterone support is an established component of many fertility-treatment protocols.
The purpose is to provide progesterone during the luteal phase and support the endometrium following assisted reproductive treatment. The particular preparation may be injectable, vaginal or another pharmaceutical form depending on the protocol and country.
UK fertility services currently identify Prontogest 100mg/mL as one injectable progesterone option used in ART treatment.
This distinction is important for both SEO accuracy and product-page accuracy.
A product labelled 100mg/1mL contains 100mg progesterone in each 1mL of solution.
A product labelled 100mg/2mL contains 100mg progesterone in each 2mL presentation.
Therefore, “Progesterone 100mg Injection” alone does not uniquely identify the concentration.
Current market evidence includes:
The Ferring India product portfolio currently lists progesterone solution for injection at 100mg/2mL.
Gestone is a branded progesterone product marketed by Ferring in certain markets.
Current Indian medicine information identifies Gestone Injection 100mg/2mL as containing progesterone 100mg and identifies Ferring as the marketer.
Therefore, “Gestone 100mg Injection” can be an important commercial search entity where the actual product is Gestone, but a generic Progesterone 100mg Injection should not automatically be called Gestone.
Prontogest is another progesterone injection brand.
UK fertility-service information identifies Prontogest as an intramuscular 100mg/mL progesterone injection used for fertility support and specifically notes that the product is not licensed in the UK.
A product using the name “Progesterone 100mg Injection” should only be described as Prontogest when the actual manufacturer’s product corresponds to Prontogest.
Progesterone capsules and injectable progesterone are different dosage forms.
The UK eMC currently lists multiple licensed 100mg progesterone capsule products, including progesterone 100mg soft capsules and other formulations. It does not establish that a generic injectable 100mg product is equivalent to these oral or vaginal preparations.
The route of administration can alter absorption and pharmacokinetics, so the same nominal 100mg strength should not be used to imply direct substitution.
Vaginal progesterone products are widely used in reproductive medicine.
For example, Ferring UK currently lists Lutigest 100mg vaginal tablets, while other licensed progesterone products include Cyclogest and Utrogestan formulations.
These are distinct pharmaceutical products from injectable progesterone and should be described separately for both medical accuracy and SEO.
Progesterone has important physiological functions during pregnancy, and some progesterone products are used for pregnancy-support indications.
However, the approved indication depends on the specific product and jurisdiction. A progesterone injection should therefore not automatically be marketed as a universal “pregnancy injection.”
The relevant local product information should determine whether a particular injectable progesterone formulation is authorized for pregnancy-related use.
Progesterone can cause adverse effects including:
Current product information for Gestone also reports symptoms such as back pain, weight changes, nausea, abdominal discomfort and injection-site or local effects.
The exact adverse-effect profile depends on the formulation, route and patient.
Contraindications vary between products and countries, but medical assessment is particularly important in patients with:
The exact manufacturer leaflet or SmPC should always be consulted.
Progesterone may interact with medicines that influence hormone metabolism or are used concurrently in reproductive treatment.
A healthcare professional should review other medicines before treatment, especially when progesterone is being used with:
The clinical relevance of an interaction depends on the formulation and indication.
Storage requirements depend on the exact manufacturer and presentation.
For example, current information for Gestone identifies storage below 25°C, while UK fertility guidance for Prontogest also advises storage below 25°C.
The actual product label should always be followed.
The UK market requires particular care with this product.
The current Ferring UK product list includes licensed progesterone products such as Lutigest 100mg vaginal tablets, but not a standard Ferring progesterone 100mg injection.
At the same time, UK fertility services identify Prontogest 100mg/mL injection as a progesterone-support medicine used in ART and explicitly note that it is not licensed in the UK.
Accordingly, a commercial page should not state that an unspecified Progesterone 100mg Injection is a UK-licensed medicine unless the exact product has a valid UK authorization.
Australian regulatory data confirms progesterone medicines are actively registered, but current 100mg registrations identified by the TGA include oral soft capsules and other non-injectable presentations rather than establishing a universal 100mg injectable product.
Ferring’s international product portfolio varies by country and currently lists injectable progesterone in India in both 50mg/mL and 100mg/2mL presentations.
Progesterone 100mg injections are documented internationally under different brands and concentrations.
Examples include Prontogest 100mg/mL and Gestone 100mg/2mL.
Country-specific regulatory approval, formulation, prescription requirements and permitted supply channels must be checked individually.
What is Progesterone 100mg Injection?
It is an injectable progesterone medicine containing 100mg progesterone per product presentation. Depending on the manufacturer, it may be supplied as 100mg/1mL or 100mg/2mL.
What is Progesterone 100mg Injection used for?
It is used in specialist reproductive medicine, including progesterone supplementation and some assisted reproductive treatment protocols.
Is Progesterone 100mg Injection used for IVF?
Yes. Injectable progesterone such as Prontogest 100mg/mL is used in some ART and IVF support protocols.
What is Prontogest 100mg/mL?
Prontogest is a progesterone injection containing 100mg progesterone per mL and is used in some fertility-treatment protocols. UK fertility guidance identifies it as an intramuscular injection and states that it is not licensed in the UK.
What is Gestone 100mg/2mL?
Gestone is a branded progesterone injection marketed by Ferring in certain markets. Current Indian medicine information identifies the presentation as 100mg progesterone in 2mL.
Is Progesterone 100mg Injection the same as Gestone?
Not necessarily. Gestone is a specific branded product containing progesterone. An unspecified Progesterone 100mg Injection may come from another manufacturer and may have a different concentration or formulation.
Is Progesterone 100mg Injection the same as Prontogest?
Not necessarily. Prontogest is a specific progesterone injection, commonly identified as 100mg/mL. Other progesterone injections may contain 100mg in a different volume.
Is Progesterone 100mg Injection available in the UK?
The specific product must be checked. Prontogest 100mg/mL is used in some UK fertility services but is not licensed in the UK, while licensed UK progesterone products include vaginal and oral 100mg formulations.
What are common Progesterone 100mg Injection side effects?
Possible effects include headache, dizziness, drowsiness, nausea, breast tenderness, weight changes, abdominal discomfort and injection-site reactions. The exact profile depends on the product.
Does Progesterone 100mg Injection support pregnancy?
Some progesterone products are used for pregnancy-support indications, but the exact authorization depends on the formulation, product and country.
Is Progesterone 100mg Injection a prescription medicine?
Injectable progesterone products are generally prescription medicines and should be used under appropriate medical supervision.
Is Progesterone 100mg Injection available internationally?
Yes, injectable progesterone 100mg products are documented in multiple international markets, but brands, concentrations, approved indications and regulatory status vary.
Last Updated: September 19, 2026 | Medically Reviewed By: Licensed Pharmacist
Medical Disclaimer: This information is provided for educational purposes only and is not a substitute for professional medical advice, diagnosis or treatment. Injectable progesterone is a prescription hormonal medicine and should be used only under appropriate medical supervision. Always verify the exact product’s concentration, manufacturer, route, approved indications and regulatory status before use or supply.
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