Monobenzone 60% Cream

Monobenzone 60% Cream is a high-strength topical depigmenting formulation containing 60% w/w monobenzone. Commercial product listings commonly identify this formulation as Benoquin 60 and list it in a 100g pack. Monobenzone is used medically for permanent depigmentation in people with extensive or disseminated vitiligo; a 60% finished product should not be presented as equivalent to the historical U.S. FDA-approved 20% Benoquin formulation.

Product Information

Generic Name

Monobenzone

Common Product Name

Benoquin 60 / Monobenzone 60% Cream

Drug Class

Topical Depigmenting Agent

Active Ingredient

Monobenzone 60% w/w

Indication

Medical depigmentation in extensive or disseminated vitiligo

Form

Topical Cream

Strength

60% w/w

Pack Size

Commonly listed as 100g

Route

Topical / External Use

Regulatory Status

Jurisdiction-specific; 60% finished-product authorization should be verified locally

Reference Product Note

Historical U.S. FDA Benoquin labeling was for 20% monobenzone, not 60%.

Monobenzone 60% vs Benoquin 20%

The terms monobenzone and Benoquin refer to the same active ingredient/product family, but the strength matters.

Historical U.S. FDA documentation concerns Benoquin Cream 20%, indicated for final depigmentation in extensive vitiligo. The FDA later noted that this 20% product was no longer being manufactured or distributed and had been de-listed. A commercially listed Benoquin 60 / Monobenzone 60% product is therefore a different-strength finished formulation and should not be described as FDA-approved simply because monobenzone or Benoquin 20% has historical FDA documentation.

UK & International Availability

Search demand for monobenzone 60 cream, Benoquin 60 monobenzone cream, monobenzone cream USP 60, monobenzone cream UK, and related product queries shows a clear product-specific search pattern around the 60% formulation. Current commercial listings commonly identify Benoquin 60 as a 60% w/w cream in 100g packaging.

For UK customers, regulatory status should be checked for the specific finished product rather than inferred from the existence of monobenzone as an active substance. MHRA records include monobenzone in active-substance registration records, but an API registration does not by itself establish authorization of a particular 60% finished cream in the UK.

Orders and international delivery should therefore be subject to applicable prescription, importation, and medicines regulations in the destination country.

How it works

The exact mechanism of monobenzone is not fully understood. FDA labeling for Benoquin describes increased melanin loss from melanocytes and notes that monobenzone may cause destruction of melanocytes, resulting in permanent depigmentation.

A 60% formulation contains 600mg of monobenzone per gram of cream based on the stated 60% w/w concentration.

Monobenzone is a potent depigmenting agent used for final depigmentation in extensive vitiligo. The historical U.S. Benoquin 20% labeling specified use in disseminated idiopathic vitiligo involving more than 50% of body surface area. It is not intended as an ordinary cosmetic skin-lightening cream and should not be marketed for freckles, melasma, tanning, or routine pigmentation concerns.

Because monobenzone can produce permanent pigment loss, treatment selection and monitoring should be handled by an appropriately qualified healthcare professional.

Monobenzone is a potent depigmenting agent and can cause irreversible or permanent depigmentation. The historical Benoquin label also describes skin irritation, sensitization, burning, dermatitis, unintended depigmentation at sites away from the application area, and long-term sensitivity to sunlight after depigmentation.

Monobenzone should not be treated as a substitute for hydroquinone and should not be promoted as a routine cosmetic bleaching ingredient. Localized or inappropriate use can produce uneven or unintended pigment loss.

Use should be determined by a qualified healthcare professional, with the product label and applicable local regulations followed.