Drug: Bupropion Hydrochloride | Class: NDRI Antidepressant / Nicotine Receptor Antagonist | Brand: Wellbutrin (GSK); Zyban for smoking; Bupron (Sun Pharma India) | Indication: Depression, smoking cessation (Zyban), ADHD (off-label), seasonal affective disorder | Dose: Depression: 150mg SR once daily for 3 days, then 150mg twice daily
Quick Answer — What is Bupropion used for?
Bupropion is used for depression, smoking cessation (zyban), adhd (off-label), seasonal affective disorder. FDA-approved for depression and smoking cessation; no sexual dysfunction (unlike SSRIs); seizure risk dose-dependent. Always start at the lowest dose and titrate under physician supervision.
Bupropion – NDRI Antidepressant / Nicotine Receptor Antagonist
Bupropion contains Bupropion Hydrochloride, a ndri antidepressant / nicotine receptor antagonist for depression, smoking cessation (zyban), adhd (off-label), seasonal affective disorder. FDA-approved for depression and smoking cessation; no sexual dysfunction (unlike SSRIs); seizure risk dose-dependent.
Product Information
| Attribute |
Details |
| Generic Name |
Bupropion Hydrochloride |
| Drug Class |
NDRI Antidepressant / Nicotine Receptor Antagonist |
| Brand Reference |
Wellbutrin (GSK); Zyban for smoking; Bupron (Sun Pharma India) |
| Indication |
Depression, smoking cessation (Zyban), ADHD (off-label), seasonal affective disorder |
| Standard Dose |
Depression: 150mg SR once daily for 3 days, then 150mg twice daily. Maximum 300mg/day. Smoking: 150mg/day × 3 days, then 150mg twice daily × 7–12 weeks |
| Form |
Tablet |
| Route |
Oral |
| Prescription |
Yes |
| Evidence |
FDA-approved for depression and smoking cessation; no sexual dysfunction (unlike SSRIs); seizure risk dose-dependent |
How It Works
Norepinephrine-dopamine reuptake inhibition.
People Also Ask
How long does Bupropion take to work?
Most antidepressants require 2–4 weeks to produce noticeable improvement, with full effect at 6–8 weeks.
Can Bupropion be stopped suddenly?
Never stop antidepressants abruptly — discontinuation syndrome (dizziness, flu-like symptoms, electric shock sensations) can occur. Taper gradually over weeks under physician supervision. SSRIs/SNRIs and paroxetine particularly require slow tapering. TCAs should be reduced slowly.
Does Bupropion cause sexual dysfunction?
SSRIs and many TCAs cause sexual dysfunction (reduced libido, delayed orgasm) in 30–60% of patients — a major cause of non-adherence. Bupropion is uniquely associated with minimal or no sexual dysfunction. Mirtazapine, tianeptine, and agomelatine also have lower sexual dysfunction rates.
Is Bupropion addictive?
Standard antidepressants do not cause addiction in the classical sense, though physical discontinuation symptoms can occur with abrupt stopping.
Can Bupropion and alcohol be combined?
Alcohol and antidepressants/anxiolytics interact unfavourably — increased CNS depression, worsened mood, reduced efficacy. Alcohol should be minimised or avoided during treatment with any psychotropic medication.
Storage
Store at 15–30°C away from sunlight and moisture. Keep out of reach of children.
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