Neo Mercazole 10mg Tablet

Carbimazole – Antithyroid / Thyroid Hormone Synthesis Inhibitor

Carbimazole contains Carbimazole, a antithyroid / thyroid hormone synthesis inhibitor for hyperthyroidism — graves’ disease, toxic nodular goitre, pre-operative preparation. BNF UK first-line antithyroid drug; ATA guideline antithyroid; rapidly converted to methimazole in the body.

Product Information

How It Works

Inhibits thyroid peroxidase blocking T3/T4 synthesis; prodrug of methimazole.

People Also Ask

What is the difference between Carbimazole and levothyroxine?

Levothyroxine is T4 replacement for hypothyroidism. Carbimazole BLOCKS thyroid hormone production for hyperthyroidism. They are treatments for opposite conditions — never interchange.

How is Carbimazole monitored?

TSH blood tests every 6–8 weeks until stable, then annually. For carbimazole: CBC monitoring for agranulocytosis. For T3: more frequent TSH monitoring due to faster T3 fluctuations.

Can Carbimazole be taken in pregnancy?

Hypothyroidism in pregnancy requires careful management — TSH targets are tighter (0.1–2.5 mU/L). Levothyroxine dose usually increases 25–30% in pregnancy. Carbimazole: use PTU in first trimester (methimazole/carbimazole avoided due to foetal abnormality risk). Liothyronine: minimal data, generally avoided in pregnancy.

What foods interact with Carbimazole?

Calcium supplements, iron, antacids, and high-fibre foods reduce levothyroxine absorption — separate by 4 hours. Soy products modestly reduce T4 absorption. Carbimazole and liothyronine have fewer food interactions but maintain consistent dosing times.

Does Carbimazole cause weight changes?

Treating hypothyroidism (levothyroxine, liothyronine): 2–5kg modest weight loss as metabolic rate normalises. Treating hyperthyroidism (carbimazole): weight gain of 2–4kg as normalised thyroid function reduces hypermetabolism.

Storage

Store at 15–30°C away from sunlight and moisture. Keep out of reach of children.